Abstract
Advanced germinal cells (spermatocytes and spermatids) prepared from adult rat testes, but not other cells, released their cellular contents into the incubation medium when they were incubated at 37° at a physiological pH. Evidence was presented that the release of cellular contents was due to changes in the permeability of the plasma membranes of these cells. The hypothesis is advanced that the changes in the permeability of the plasma membranes of the advanced testicular germinal cells of the rat may be intimately associated with the cellular degeneration and cessation of spermatogenesis which occur in cryptorchid testes.

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