Fluctuations in the production of specific cellular peptides during the growth of animal cells.

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Abstract
Patterns of newly synthesized proteins of [African green monkey kidney] Vero cells in different growth states were obtained using 2-dimensional gel electrophoresis. The 240 most prevalent peptide spots were then compared. Cells in exponential growth and in the stationary phase had patterns of peptide spots characteristic of their state of growth. The transition between these patterns is progressive, and the cells acquired a pattern characteristic of quiescent cells by the late exponential phase. Apparently a series of modulations in gene expression occurs during the transition of growth states in animal cells that leads to the specific appearance or disappearance of certain cellular peptides.