Nonaqueous capillary electrophoresis — its applicability in the analysis of food, pharmaceuticals and biological fluids
- 1 September 1998
- journal article
- review article
- Published by Wiley in Electrophoresis
- Vol. 19 (12) , 2179-2186
- https://doi.org/10.1002/elps.1150191223
Abstract
The use of nonaqueous electrophoresis media for the application of capillary electrophoresis in the analysis of food, pharmaceuticals and biological fluids is reviewed. Some of the applications are discussed in detail and the benefits of using nonaqueous media in these cases are outlined. Three new applications within pharmaceutical analyses are presented. In these methods either a simple sample pretreatment by dilution with methanol (determination of chlorhexidine in a cream) or selective on‐line capillary electrophoresis mass spectrometry (methods for identification of seizure drugs or opium alkaloids) are used. The choice of organic solvents and electrolytes for nonaqueous capillary electrophoresis are discussed. Furthermore, validation data obtained using capillary electrophoresis based on the nonaqueous principle are listed and discussed.Keywords
This publication has 31 references indexed in Scilit:
- Validation of a simple method for the determination of oxytetracycline in ointment by non-aqueous capillary electrophoresisJournal of Pharmaceutical and Biomedical Analysis, 1997
- Quantitative description of migration behavior of porphyrins based on the dynamic complexation model in a nonaqueous capillary electrophoresis systemElectrophoresis, 1997
- Chiral Separations by Nonaqueous Capillary ElectrophoresisAnalytical Chemistry, 1996
- Determination of opium alkaloids in crude opium using non-aqueous capillary electrophoresisJournal of Pharmaceutical and Biomedical Analysis, 1995
- Separation of Tamoxifen and Metabolites by Capillary Electro-Phoresis with Non-aqueous Buffer SystemJournal of Liquid Chromatography, 1994
- Nonaqueous Capillary ElectrophoresisAnalytical Chemistry, 1994
- Nonaqueous solvents in the on‐line capillary electrophoresis‐mass spectrometry analysis of drug metabolitesJournal of High Resolution Chromatography, 1994
- Study of in Vivo pyrazoloacridine metabolism by capillary electrophoresis using isotachophoresis preconcentration in non‐aqueous separation bufferJournal of High Resolution Chromatography, 1993
- Electrophoresis in synthetic organic polymer capillaries: variation of electroosmotic velocity and .zeta. potential with pH and solvent compositionAnalytical Chemistry, 1992
- Electrophoresis in fused-silica capillaries: the influence of organic solvents on the electroosmotic velocity and the .zeta. potentialAnalytical Chemistry, 1991