The Regulation of NADP-linked Isocitrate Dehydrogenase in Aspergillus nidulans

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Abstract
The regulation of NADP-linked isocitrate dehydrogenase (NADP-IDH) has been studied in wild-type and mutant strains of A. nidulans. In the wild-type strain, the levels vary in a similar way to those of acetamidase, acetyl-CoA synthase (EC 6.2.1.1), isocitrate lyase (EC 4.1.3.1) and malate synthase (EC 4.1.3.2) under all growth conditions used. Similarly, fac mutants, which are altered in the regulation of these enzymes of acetate utilization, are affected in NADP-IDH levels in a parallel fashion, as are cre mutants, which show altered C catabolite repression of this group of enzymes. Possible functions of the NADP-IDH enzyme are considered.