Tandem Intramolecular Silylformylation−Crotylsilylation: Highly Efficient Synthesis of Polyketide Fragments
- 12 June 2002
- journal article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 124 (27) , 7890-7891
- https://doi.org/10.1021/ja026511y
Abstract
Polyketide fragments may be rapidly and efficiently assembled in the tandem intramolecular silylformylation−crotylsilylation of alkenes and alkynes. The reactions establish up to three new stereocenters with good-to-excellent diastereoselectivity, and the use of the reaction in an iterative sense is demonstrated. In addition, a new dihydrosilane alcoholysis reaction has been developed, leading to a highly efficient sequence.Keywords
This publication has 4 references indexed in Scilit:
- Tandem Intramolecular Alkyne Silylformylation-Allylsilylation: A Case of Remote 1,5-Asymmetric InductionAngewandte Chemie International Edition in English, 2001
- Formal Total Synthesis of Mycoticin AJournal of the American Chemical Society, 2000
- Tandem Intramolecular Silylformylation−AllylsilylationJournal of the American Chemical Society, 2000
- The condensation reaction of trichlorosilane with allylic chlorides catalyzed by copper salts in the presence of a tertiary amineJournal of Organometallic Chemistry, 1975