Hypoxia-Inducible Factor 1α in Clear Cell Renal Cell Carcinoma
Open Access
- 15 December 2007
- journal article
- Published by American Association for Cancer Research (AACR) in Clinical Cancer Research
- Vol. 13 (24) , 7388-7393
- https://doi.org/10.1158/1078-0432.ccr-07-0411
Abstract
Purpose: Hypoxia-inducible factor-1α (HIF-1α) plays an important role in tumoral adaptation to hypoxic conditions by serving as a transcription factor for several crucial proteins, including vascular endothelial growth factor and carbonic anhydrase IX (CAIX). Here, we evaluated the significance of HIF-1α in renal cell carcinoma (RCC).Keywords
This publication has 39 references indexed in Scilit:
- Hypoxia-Inducible Factor 1α Expression in Renal Cell Carcinoma Analyzed by Tissue MicroarrayEuropean Urology, 2006
- Mammalian Target of Rapamycin Inhibitors in Renal Cell Carcinoma: Current Status and Future ApplicationsSeminars in Oncology, 2006
- Effect of Antisense Hypoxia-inducible Factor 1?? on Progression, Metastasis, and Chemosensitivity of Pancreatic CancerPancreas, 2006
- Role of Carbonic Anhydrases in the Progression of Renal Cell Carcinoma Subtypes: Proposal of a Unified HypothesisCancer Investigation, 2006
- Carbonic Anhydrase IX Expression Predicts Outcome of Interleukin 2 Therapy for Renal CancerClinical Cancer Research, 2005
- Cell cycle kinase inhibitor expression and hypoxia-induced cell cycle arrest in human cancer cell linesCarcinogenesis: Integrative Cancer Research, 2004
- Strict regulation of CAIXG250/MN by HIF-1α in clear cell renal cell carcinomaOncogene, 2004
- VEGF and the quest for tumour angiogenesis factorsNature Reviews Cancer, 2002
- Tissue microarrays for high-throughput molecular profiling of tumor specimensNature Medicine, 1998
- Purification and Characterization of Hypoxia-inducible Factor 1Journal of Biological Chemistry, 1995