MULTILOCUS LINKAGE ANALYSIS IN HUMANS - DETECTION OF LINKAGE AND ESTIMATION OF RECOMBINATION
- 1 January 1985
- journal article
- research article
- Vol. 37 (3) , 482-498
Abstract
Multilocus linkage analysis is investigated from the viewpoint of the efficiency of recombination estimates under different strategies for detecting linkage and determining gene order within a linkage group. The appropriateness of assuming no interference with data available in human genetic studies is considered. Examples are given to show the significance of multilocus analysis in humans. A computer program package, linkage, for multilocus linkage analysis is described.This publication has 16 references indexed in Scilit:
- Strategies for multilocus linkage analysis in humans.Proceedings of the National Academy of Sciences, 1984
- Easy calculations of lod scores and genetic risks on small computers.1984
- Statistical Analysis of Multilocus RecombinationBiometrics, 1983
- Beta-globin locus is linked to the parathyroid hormone (PTH) locus and lies between the insulin and PTH loci in man.Proceedings of the National Academy of Sciences, 1983
- The use of computersCytogenetic and Genome Research, 1982
- An alternative model of recombination and interferenceAnnals of Human Genetics, 1979
- Classifications and comparisons of multilocus recombination distributionsProceedings of the National Academy of Sciences, 1978
- A Mapping Function for ManHuman Heredity, 1977
- A mapping function for human chromosomesAnnals of Human Genetics, 1976
- A General Model for the Genetic Analysis of Pedigree DataHuman Heredity, 1971