Evidence of an Estrogen-Like Effect of Dehydroepiandrosterone On Lysyl Oxidase Activity in the Mouse Cervix

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Abstract
The effect of dehydroepiandrosterone (DHA) on the lysyl oxidase activity in the mouse cervix was studied. Injection of animals ovariectomized 10 days before with 1 mg DHA was followed 24 h later by an increase in enzyme activity, which remained unaltered for 48 h, returning to control values by 96 h after injection. At least 100 .mu.g of DHA was required to increase enzyme activity; the maximum effect occurred with 1 mg of the steroid and was comparable to that of 1 .mu.g estradiol-17.beta.. These results demonstrate an estrogen-like effect of DNA on lysyl oxidase activity in mouse cervix. The onset of response was later and the duration of response was longer for DNA than for estradiol-17.beta.