Viral complementation allows HIV-1 replication without integration
Open Access
- 9 July 2008
- journal article
- Published by Springer Nature in Retrovirology
- Vol. 5 (1) , 60
- https://doi.org/10.1186/1742-4690-5-60
Abstract
The integration of HIV-1 DNA into cellular chromatin is required for high levels of viral gene expression and for the production of new virions. However, the majority of HIV-1 DNA remains unintegrated and is generally considered a replicative dead-end. A limited amount of early gene expression from unintegrated DNA has been reported, but viral replication does not proceed further in cells which contain only unintegrated DNA. Multiple infection of cells is common, and cells that are productively infected with an integrated provirus frequently also contain unintegrated HIV-1 DNA. Here we examine the influence of an integrated provirus on unintegrated HIV-1 DNA (uDNA).Keywords
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