CAFFEINE SENSITIVITY IN THE NEONATAL RAT
- 1 January 1982
- journal article
- research article
- Vol. 4 (3) , 331-333
Abstract
The motor activity of infants rats as 1, 10 and 15 days of age was determined following treatment with caffeine, a CNS stimulant. At all 3 ages responses to increasing caffeine dosage described a curvilinear function in which activity first increased and then decreased. The basic adult response pattern to caffeine is exhibited by infants as young as 1 day of age. One-day-old rats were less sensitive to caffeine than the 10- and 15-day-old pup. Their maximal activity was reached at the 80 mg/kg dosage while 10- and 15-day-old rats were most active in the 20-40 mg/kg dose range. Apparently, neonatal rat can be used to assess the behavioral effects of exposure to environmental agents during development.This publication has 7 references indexed in Scilit:
- CAFFEINE - EFFECTS OF ACUTE AND CHRONIC EXPOSURE ON THE BEHAVIOR OF NEONATAL RATS1982
- Acute effects of caffeine in normal prepubertal boysAmerican Journal of Psychiatry, 1981
- Ontogeny of amphetamine anorexia in rats: A behavioral analysis.Journal of Comparative and Physiological Psychology, 1981
- Ontogeny of behavioral arousal: The role of environmental stimuli.Journal of Comparative and Physiological Psychology, 1978
- Postnatal development of dopaminergic and cholinergic catalepsy in the ratEuropean Journal of Pharmacology, 1976
- EFFECT OF CAFFEINE ON LOCOMOTOR ACTIVITY AND CENTRAL CATECHOLAMINE MECHANISMS: A STUDY WITH SPECIAL REFERENCE TO DRUG INTERACTIONActa Pharmacologica et Toxicologica, 1975
- PSYCHOTROPIC EFFECTS OF CAFFEINE IN MAN .I. INDIVIDUAL DIFFERENCES IN SENSITIVITY TO CAFFEINE-INDUCED WAKEFULNESS1965