Analogs of the cytostatic cyclic tetrapeptide chlamydocin. Synthesis of N.beta.-(N-maleoylglycyl) and N.beta.-(tert-butyloxycarbonyl) derivatives of cyclo(Gly-L-Phe-D-Pro-L-Dap)
- 1 May 1981
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 24 (5) , 567-572
- https://doi.org/10.1021/jm00137a017
Abstract
The synthesis of analogs of the cytostatic [antitumor] cyclic tetrapeptide chlamydocin is described. The maleoyl cyclic tetrapeptide did not inhibit [3H]thymidine incorporation into calf thymus lymphocytes at concentrations 1000-fold higher than the IC50 for chlamydocin (6 nM).This publication has 2 references indexed in Scilit:
- Observation of 3 .fwdarw. 1 intramolecular hydrogen bonds (.gamma. turns) in the cyclic tetrapeptides, [Ala4]-desdimethylchlamydocin and cyclo-(D-Phe-Pro-D-Phe-Pro), by NMR spectrometry. Effect of solvent on solution conformationJournal of the American Chemical Society, 1980
- Tumor inhibitors having potential for interaction with mercapto enzymes and/or coenzymesBioorganic Chemistry, 1977