DISTRIBUTION AND DEVELOPMENT OF ANGIOTENSIN CONVERTING ENZYME IN FETAL AND NEWBORN RABBIT - IMMUNOFLUORESCENCE STUDY

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  • 1 January 1978
    • journal article
    • research article
    • Vol. 38  (5) , 581-585
Abstract
The distribution and development of angiotensin converting enzyme (EC 3.4.15.1) were studied in fetal and newborn rabbits, using fixed tissues embedded in paraffin and stained with a fluorescein-conjugated antibody specific for the enzyme. The enzyme was found at the luminal plasma membrane of endothelial cells from the 2nd third of gestation to the neonatal period. Two types of epithelial cells also contained the enzyme, renal tubular and intestinal. The vascular enzyme may play a role in the regulation of its vasoaction peptide substrates, angiotensin and bradykinin, at term.