The structure of cerexin B. Studies on antibiotics from the genus Bacillus. XVII.
- 1 January 1976
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 29 (12) , 1275-1280
- https://doi.org/10.7164/antibiotics.29.1275
Abstract
The structure of cerexin B [antibacterial antibiotic] was examined. The constituent fatty acids were elucidated by gas chromatography and mass spectrometry to be .beta.-hydroxy isodecanoic acid, .beta.-hydroxy decanoic acid, .beta.-hydroxy isoundecanoic acid and .beta.-hydroxy anteisoundecanoic acid. The configurations of constituent amino acids were determined as asparagine (2D, 1L), valine (D), phenylalanine (D), allo-threonine (D), tryptophan (D), and allo-isoleucine (D) from their optical activities. Treatment with concentrated HCl cleaved at the .gamma.-hydroxylysine residue to give 2 peptide fragments, 1 of which (the N-terminal side) was then deacylated with polymyxin acylase. Their amino acid sequences were examined by Edman degradation. From the results and analogy to cerexin A, the structure of cerexin B was deduced.This publication has 2 references indexed in Scilit:
- Studies on antibiotics from the genus Bacillus. X. The structure of brevistin.The Journal of Antibiotics, 1976
- The total structure of cerexin A. Studies on antibiotics from the genus Bacillus. XVI.The Journal of Antibiotics, 1976