Clinical Evaluation of a Pre‐Set Ultrafiltration Rate Controller Available for Single Pass and Hemodiafiltration Systems

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Abstract
Introduction of high flux-type human dialyzers, such as the RP-6, makes it necessary to devise an ultrafiltration rate controller for a single pass system. For this purpose, a new pre-set ultrafiltration rate controller was developed and examined experimentally and clinically. The controller has twin chambers, each of which is divided into 2 symmetrical parts by a vertically-placed diaphragm. The diaphragm shifts repeatedly from right to left, aspirating in and driving out fresh or used dialysate alternately. If one removes a certain amount of used dialysate from a branch of the efferent line, negative pressure develops and aspirates an equal amount of water from the dialyzer. Extra dialysate obtained by a pump precisely reflects ultrafiltration rate. The controller has been used on 5 patients. The scheduled ultrafiltration rate was easily obtainable. The apparatus is also available for hemodiafiltration. Initial clinical trial was promising.

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