In Vitro Exchange of Fluoroquinolone Resistance Determinants betweenStreptococcus pneumoniaeand Viridans Streptococci and Genomic Organization of theparE‐parCRegion inS. mitis
Open Access
- 1 August 1999
- journal article
- Published by Oxford University Press (OUP) in The Journal of Infectious Diseases
- Vol. 180 (2) , 555-558
- https://doi.org/10.1086/314888
Abstract
Transfer of fluoroquinolone (FQ) resistance determinants between Streptococcus pneumoniae and viridans streptococci was explored by transformation in vitro. One-step FQ-resistant parC mutants were selected, and resistance could be transferred from DNA from S. oralis, S. mitis, S. sanguis, and S. constellatus to S. pneumoniae, with frequencies of 10 −3 to 90% homology with that of S. pneumoniae. The efficient interspecific transfer of quinolone resistance determinants in vitro leads us to anticipate their dissemination in the clinical setting.Keywords
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