EFFECTS OF DIISOPROPYL FLUOROPHOSPHATE (DFP) ON ACETYLCHOLINE STIMULATION OF THE FROG RECTUS ABDOMINIS MUSCLE
- 31 October 1947
- journal article
- research article
- Published by American Physiological Society in American Journal of Physiology-Legacy Content
- Vol. 151 (1) , 107-109
- https://doi.org/10.1152/ajplegacy.1947.151.1.107
Abstract
Response of the isolated rectus abdominis muscle to acetylcholine is potentiated by DFP. Part of this effect is believed due to the acid properties of DFP since potentiation of response to acetylcholine is considerably greater in an unbuffered soln. of DFP. It is therefore suggested that the anticholinesterase activity of DFP is mediated by 2 effects: a) the acidity of DFP due to its structural similarity to phosphoric acid and b) the specific anticholinesterase activity of DFP itself.Keywords
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