Insulin receptor substrate (IRS) transduction system: distinct and overlapping signaling potential
- 14 November 2000
- journal article
- review article
- Published by Wiley in Diabetes/Metabolism Research and Reviews
- Vol. 16 (6) , 434-441
- https://doi.org/10.1002/1520-7560(2000)9999:9999<::aid-dmrr159>3.0.co;2-8
Abstract
Insulin receptor substrate (IRS) proteins play a central role in maintaining basic cellular functions such as growth and metabolism. They act as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as the insulin receptor, and a complex network of intracellular signalling molecules containing Src homology 2 (SH2) domains. Four members (IRS‐1, IRS‐2, IRS‐3, IRS‐4) of this family have been identified which differ in their subcellular distribution and interaction with SH2 domain proteins. In addition, differential IRS tissue‐ and developmental‐specific expression patterns may contribute to specificity in their signaling potential. Copyright © 2000 John Wiley & Sons, Ltd.Keywords
This publication has 46 references indexed in Scilit:
- Insulin receptor variant forms and Type 2 diabetes mellitusPharmacogenomics, 2000
- A Novel 160-kDa Phosphotyrosine Protein in Insulin-treated Embryonic Kidney Cells Is a New Member of the Insulin Receptor Substrate FamilyJournal of Biological Chemistry, 1997
- The insulin signalling system and the IRS proteinsDiabetologia, 1997
- The 60-kDa Phosphotyrosine Protein in Insulin-treated Adipocytes Is a New Member of the Insulin Receptor Substrate FamilyJournal of Biological Chemistry, 1997
- Insulin Receptor Substrate 1 Rescues Insulin Action in CHO Cells Expressing Mutant Insulin Receptors That Lack a Juxtamembrane NPXY MotifMolecular and Cellular Biology, 1995
- Role of IRS-2 in insulin and cytokine signallingNature, 1995
- Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 geneNature, 1994
- Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1Nature, 1994
- IRS-1: Essential for Insulin- and IL-4-Stimulated Mitogenesis in Hematopoietic CellsScience, 1993
- Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction proteinNature, 1991