Opposite effects of morphine on feeding and drinking in rats relative to administration time.
- 1 January 1983
- journal article
- research article
- Published by Elsevier in The Japanese Journal of Pharmacology
- Vol. 33 (4) , 829-835
- https://doi.org/10.1254/jjp.33.829
Abstract
How morphine changes food and water intake in non-fasted or fasted rats with different administration times was studied. Morphine (1, 3 and 10 mg/kg) was administered i.p. at 1045 h (light period) or 1845 h (dark period). Morphine increased food and water intake in non-fasted rats 2 h after the administration during the light period, whereas the total daily intakes were decreased. Morphine decreased food and water intake in non-fasted rats during the dark period and in fasted rats during both the light and dark period. Morphine apparently disorders the baseline levels of feeding and water drinking of naive rats.This publication has 0 references indexed in Scilit: