Inflammatory Cytokines Inhibit Kaposi's Sarcoma-Associated Herpesvirus Lytic Gene Transcription in In Vitro-Infected Endothelial Cells
Open Access
- 1 March 2004
- journal article
- research article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 78 (5) , 2591-2596
- https://doi.org/10.1128/jvi.78.5.2591-2596.2004
Abstract
The response of Kaposi's sarcoma (KS)-associated herpesvirus (KSHV) to inflammatory cytokine treatment of experimentally infected endothelial cells was investigated. The cytokines inhibited spontaneous KSHV lytic gene expression but not the level of infection. The data suggest that if inflammatory cytokines present in KS lesions contribute to KSHV pathogenesis, they do so in part by promoting latent KSHV infection of the endothelial cells.Keywords
This publication has 35 references indexed in Scilit:
- The molecular pathology of Kaposi’s sarcoma-associated herpesvirusBiochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2002
- Octamer-Binding Sequence Is a Key Element for the Autoregulation of Kaposi's Sarcoma-Associated Herpesvirus ORF50/Lyta Gene ExpressionJournal of Virology, 2001
- Biology of Kaposi's sarcomaEuropean Journal Of Cancer, 2001
- Molecular virology of Kaposi's sarcoma–associated herpesvirusPhilosophical Transactions Of The Royal Society B-Biological Sciences, 2001
- Induction of HHV-8 Lytic Cycle Replication by Inflammatory Cytokines Produced by HIV-1-Infected T CellsThe American Journal of Pathology, 2000
- Differential Viral Protein Expression in Kaposi's Sarcoma-Associated Herpesvirus-Infected DiseasesThe American Journal of Pathology, 2000
- Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptorsNature, 1997
- Cyclin encoded by KS herpesvirusNature, 1996
- Identification of Herpesvirus-Like DNA Sequences in AIDS-Sssociated Kaposi's SarcomaScience, 1994
- ACQUIRED IMMUNODEFICIENCY SYNDROME IS AN OPPORTUNISTIC INFECTION AND KAPOSI'S SARCOMA RESULTS FROM SECONDARY IMMUNE STIMULATIONThe Lancet, 1983