The difluoromethylenephosphonate moiety as a phosphate mimic: X-ray structure of 2-amino-1,1-difluoroethylphosphonic acid
- 1 January 1990
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 15,p. 1053-1054
- https://doi.org/10.1039/c39900001053
Abstract
The synthesis and structure of 2-amino-1,1-difluorophosphonic acid (3) are described, providing the first X-ray crystal structure determination of a difluoromethylenephosphonate moiety; the structure allows an isosteric comparison to be drawn between the phosphate C–O–P bond angle and the phosphonate C–CF2–P and C–CH2–P bond angles with particular reference to the use of phosphonates as phosphate mimics in biological systems.Keywords
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