The chemistry of indoles. XXXIII Substituent effect in regioselective metalation of 3-indolecarbaldehyde and syntheses of indoles carrying a carbon side chain at the 4-, 5-, 6-, or 7-position.
Open Access
- 1 January 1986
- journal article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 34 (10) , 4116-4125
- https://doi.org/10.1248/cpb.34.4116
Abstract
The nature of a substituent on the pyrrole ring of 3-indolecarbaldehyde plays a significant role in governing the regioselectivity of metalation. To confirm the structures of the products, varios indoles carrying a carbon side chain at the 4-, 5-, 6-, or 7-position were prepared by other methods.Synthesis of 5-substituted 1-hydroxyindoles is also describedKeywords
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