Efficient synthesis of a new, highly versatile chiral derivatizing agent, α-cyano-α-fluoro-p-tolylacetic acid (CFTA)
- 1 January 1998
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Chemical Communications
- No. 3,p. 365-366
- https://doi.org/10.1039/a707755f
Abstract
The new and versatile chiral derivatizing agent, α-cyano-α- fluoro-p-tolylacetic acid (CFTA), has been efficiently synthesized in optically pure form by Candida rugosa lipase-mediated kinetic resolution of racemic CFTA ethyl ester, the latter being readily prepared by fluorination of ethyl α-cyano-p-tolylacetate with FClO3.Keywords
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