Critical Role of a Single Position in the −35 Element for Promoter Recognition by Mycobacterium tuberculosis SigE and SigH
- 15 March 2008
- journal article
- Published by American Society for Microbiology in Journal of Bacteriology
- Vol. 190 (6) , 2227-2230
- https://doi.org/10.1128/jb.01642-07
Abstract
Mycobacterial SigE and SigH both initiate transcription from the sigB promoter, suggesting that they recognize similar sequences. Through mutational and primer extension analyses, we determined that SigE and SigH recognize nearly identical promoters, with differences at the 3′ end of the −35 element distinguishing between SigE- and SigH-dependent promoters.Keywords
This publication has 16 references indexed in Scilit:
- Molecular Basis of the Defective Heat Stress Response inMycobacterium lepraeJournal of Bacteriology, 2007
- Polyphosphate kinase is involved in stress‐induced mprAB‐sigE‐rel signalling in mycobacteriaMolecular Microbiology, 2007
- Evidence for complex interactions of stress-associated regulons in an mprAB deletion mutant of Mycobacterium tuberculosisMicrobiology, 2007
- Redox-dependent Changes in RsrA, an Anti-sigma Factor in Streptomyces coelicolor: Zinc Release and Disulfide Bond FormationJournal of Molecular Biology, 2003
- Deletionof Mycobacterium tuberculosis Sigma Factor E Results inDelayed Time to Death with Bacterial Persistence in the Lungsof Aerosol-InfectedMiceInfection and Immunity, 2003
- The Mycobacterium tuberculosis ECF sigma factor σE: role in global gene expression and survival in macrophages†Molecular Microbiology, 2001
- Differential expression of 10 sigma factor genes in Mycobacterium tuberculosisMolecular Microbiology, 1999
- sigma R, an RNA polymerase sigma factor that modulates expression of the thioredoxin system in response to oxidative stress in Streptomyces coelicolor A3(2)The EMBO Journal, 1998
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequenceNature, 1998
- A mycobacterial extracytoplasmic function sigma factor involved in survival following stressJournal of Bacteriology, 1997