Cloning of a Membrane Protein That Induces a Slow Voltage-Gated Potassium Current
- 18 November 1988
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 242 (4881) , 1042-1045
- https://doi.org/10.1126/science.3194754
Abstract
A rat kidney messenger RNA that induces a slowly activating, voltage-dependent potassium current on its expression in Xenopus oocytes was identified by combining molecular cloning with an electrophysiological assay. The cloned complementary DNA encodes a novel membrane protein that consists of 130 amino acids with a single putative transmembrane domain. This protein differs from the known ion channel proteins but is involved in the induction of selective permeation of potassium ions by membrane depolarization.This publication has 24 references indexed in Scilit:
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