Experimental allergic encephalomyelitis
- 1 January 1979
- journal article
- research article
- Published by Springer Nature in Acta Neuropathologica
- Vol. 48 (3) , 171-175
- https://doi.org/10.1007/bf00690517
Abstract
Previous studies have shown that Strain 13 guinea pigs sensitised for experimental allergic encephalomyelitis (EAE) as adults usually develop an acute, fatal form of disease while animals inoculated as juveniles usually display a chronic relapsing form. The present study reports that following repeated short-interval blood sampling by cardiac puncture for the estimation of lymphocyte populations, some adult Strain 13 guinea pigs sensitised for acute EAE unexpectedly survived and developed chronic EAE, while a group of juveniles sensitised for chronic EAE and bled under the same conditions, developed a more severe, acute form of EAE. It is suggested that this reversal of disease course was related to the depletion of circulating factors.Keywords
This publication has 12 references indexed in Scilit:
- Chronic relapsing experimental allergic encephalomyelitis: Correlation of circulating lymphocyte fluctuations with disease activity in suppressed and unsuppressed animalsJournal of the Neurological Sciences, 1979
- Suppression of Chronic Allergic Encephalomyelitis: Relevance to Multiple SclerosisScience, 1978
- Experimental allergic encephalomyelitis in inbred guinea pigs: Correlation of decrease in early T cells with clinical signs in suppressed and unsuppressed animalsCellular Immunology, 1977
- Progressive Demyelination and Reparative Phenomena in Chronic Experimental Allergic EncephalomyelitisJournal of Neuropathology and Experimental Neurology, 1975
- Hyperacute, neutrophilic, and localized forms of experimental allergic encephalomyelitis: A reviewActa Neuropathologica, 1974
- Rosette-Formation between Guinea Pig Lymphoid Cells and Rabbit Erythrocytes – a Possible T-Cell MarkerInternational Archives of Allergy and Immunology, 1973
- IMMUNOGLOBULINS ON THE SURFACE OF LYMPHOCYTESThe Journal of Experimental Medicine, 1971
- Acute and Chronic Autoimmune Encephalomyelitis: Age, Strain, and Sex Dependency The Importance of the Source of AntigenExperimental Biology and Medicine, 1969
- ENCEPHALITOGEN‐INDUCED INHIBITION OF EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS: PREVENTION, SUPPRESSION AND THERAPY*Annals of the New York Academy of Sciences, 1965
- CHRONIC DISSEMINATED ALLERGIC ENCEPHALOMYELITIS IN GUINEA PIGS*Annals of the New York Academy of Sciences, 1965