Hen Egg White Ovomacroglobulin Has a Protease Inhibitory Activity1
- 1 October 1982
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Biochemistry
- Vol. 92 (5) , 1679-1682
- https://doi.org/10.1093/oxfordjournals.jbchem.a134097
Abstract
Hen egg white ovomacroglobulin purified by Miller and Feeney without reference to its activity was shown to have a protease inhibitory activity towards trypsin, papain, and thermolysin. It has four subunits of equal molecular weight (175,000 by SDS-PAGE) and each two of which are disulfide bonded. Upon incubation with trypsin it yields a fragment of Mr=80,000 plus smaller ones. The subunit composition, amino acid composition and a newly found protease inhibitory activity place ovomacroglobulin as a closely related protein to human serum a2-macroglobulin.Keywords
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