Morphine induces c-fos and junB in striatum and nucleus accumbens via D1 and N-methyl-D-aspartate receptors.
- 30 August 1994
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 91 (18) , 8537-8541
- https://doi.org/10.1073/pnas.91.18.8537
Abstract
Morphine induced the c-fos and junB immediate early genes in neurons of the medial and ventral striatum and nucleus accumbens. Induction of c-fos and junB mRNA and Fos protein was blocked by naloxone, the D1 dopamine (DA) receptor antagonists SCH23390 and SCH39166, and the N-methyl-D-aspartate (NMDA) glutamate receptor antagonist MK801. SCH23390 attenuated morphine induction of AP-1 binding in striatum, suggesting that c-fos and junB contribute to AP-1 binding. SCH23390 and MK801 did not block morphine induction of c-fos and junB in septum. Since the morphine induction of c-fos and junB in striatum and nucleus accumbens (NA) was similar to that observed with cocaine and amphetamine, these data support current concepts that limbic striatum and NA are among the brain regions that mediate drug abuse. Furthermore, since DA and NMDA receptors may mediate opiate reward and opiate induction of c-fos and junB, the DA/NMDA regulation of c-fos and junB and their target genes may produce long-term changes in the striatal and NA circuits that contribute to opiate drug abuse.Keywords
This publication has 78 references indexed in Scilit:
- Identification of an AP-1 transcription factor binding site within the human cholecystokinin (CCK) promoterNeuroReport, 1993
- Opioid receptors in midbrain dopaminergic regions of the rat I. MU receptor autoradiographyJournal Of Neural Transmission-Parkinsons Disease and Dementia Section, 1993
- N‐Methyl‐D‐Aspartate Antagonists Block Fos‐Like Protein Expression Induced via Multiple Signaling Pathways in Cultured Cortical NeuronsJournal of Neurochemistry, 1992
- Regulation of jun -B Messenger RNA and AP-1 Activity by Light and a Circadian ClockScience, 1992
- Comparative development of D1-dopamine and μ opiate receptors in normal and in 6-hydroxydopamine-lesioned neonatal rat striatum: dopaminergic fibers regulate μ but not D1 receptor distributionDevelopmental Brain Research, 1991
- D 1 and D 2 Dopamine Receptor-regulated Gene Expression of Striatonigral and Striatopallidal NeuronsScience, 1990
- Neurotransmitters and neuromodulators in the basal gangliaTrends in Neurosciences, 1990
- Molecular Characterization of Opioid ReceptorsAnnual Review of Pharmacology and Toxicology, 1990
- Morphine activation of c-fos expression in rat brainBiochemical and Biophysical Research Communications, 1988
- Morphine-induced activation of A10 dopamine neurons in the ratBrain Research, 1983