The germless theory of allergic disease: revisiting the hygiene hypothesis
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- 1 October 2001
- journal article
- review article
- Published by Springer Nature in Nature Reviews Immunology
- Vol. 1 (1) , 69-75
- https://doi.org/10.1038/35095579
Abstract
Rising rates of allergic disease accompany the healthier benefits of a contemporary westernized lifestyle, such as low infant mortality. It is likely that these twinned phenomena are causally related. The hygiene hypothesis states that allergy and increased longevity are both consequences of reducing infectious stressors during early childhood for millennia. Mechanistic explanations for the hygiene hypothesis have typically invoked the T-helper-type 1/2 (T(H)1/T(H)2) model. Here, we discuss why we favour a broader 'counter-regulatory' model--one that might also explain the increasing incidence of autoimmune disease in westernized countries.Keywords
This publication has 85 references indexed in Scilit:
- Intradermal administration of a killed Mycobacterium vaccae suspension (SRL 172) is associated with improvement in atopic dermatitis in children with moderate-to-severe diseaseJournal of Allergy and Clinical Immunology, 2001
- Siblings, Day-Care Attendance, and the Risk of Asthma and Wheezing during ChildhoodNew England Journal of Medicine, 2000
- Measles infection, measles vaccination and the effect of birth order in the aetiology of hay feverClinical and Experimental Allergy, 1998
- Sibship size, birth order, and atopy in 11,371 Italian young menJournal of Allergy and Clinical Immunology, 1998
- Interleukin-10 regulation in normal subjects and patients with asthmaJournal of Allergy and Clinical Immunology, 1996
- Interleukin-10 is a central regulator of the response to LPS in murine models of endotoxic shock and the Shwartzman reaction but not endotoxin tolerance.Journal of Clinical Investigation, 1995
- Hay fever, hygiene, and household size.BMJ, 1989
- The relationship between viral infections and onset of allergic diseases and asthmaClinical and Experimental Allergy, 1989
- Do Infections in Infancy Affect Sensitization to Airborne Allergens and Development of Atopic Disease?Allergy, 1984
- Does hyperimmunoglobulinemia-E protect tropical populations from allergic disease?Journal of Allergy and Clinical Immunology, 1983