Cyclic Changes in the Concentrations of Peripheral Blood Immune Cells During the Normal Menstrual Cycle

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Abstract
The optimal availability of immune cells in the peripheral blood streams of women may play a critical role in their response to disease and therapeutic interventions. This study was designed to examine concentrations of circulating white blood cells (WBC) including lymphocyte subsets, during the 24-hr daily and 28-day menstrual cycles. Venous blood (20 ml) from five healthy young women was obtained at 0, 6, 12, and 18 hr on the 6th and 22nd day of the normal menstrual cycle. Cortisol, progesterone (P4), estradiol (E2), total WBC, granulocyte, monocyte, and total lymphocyte levels were measured. Using fluorescent activated cell scanning, levels of T, B, Helper (H), Suppressor (S) and Natural Killer (NK) cells were also determined. Significant differences in the diurnal and Day 6 and 22 means were identified using analysis of variance and the Student's t test.

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