Treatment of Fungal Infections with Semisynthetic Derivatives of Amphotericin B
- 1 December 1988
- journal article
- Published by Wiley in Annals of the New York Academy of Sciences
- Vol. 544 (1) , 517-546
- https://doi.org/10.1111/j.1749-6632.1988.tb40449.x
Abstract
AME appeared to be as effective as AmB in the treatment of mycoses in humans. AME was much less nephrotoxic than AmB, and was better tolerated in terms of rapid onset and reversible adverse reactions. AME may be more ototoxic than AmB. AME, even as AmB and OAME, may cause neurotoxicity and leukoencephalopathy, particularly when high doses are given for long periods.Keywords
This publication has 34 references indexed in Scilit:
- ReplyThe Journal of Infectious Diseases, 1983
- Amphotericin B Methyl Ester and Leukoencephalopathy: The Other Side of the CoinThe Journal of Infectious Diseases, 1982
- Chemotherapy of Systemic Fungal DiseasesAnnual Review of Pharmacology and Toxicology, 1978
- Comparative Susceptibility of Candida albicans to Amphotericin B and Amphotericin B Methyl EsterAntimicrobial Agents and Chemotherapy, 1977
- Amphotericin B and Amphotericin B Methyl Ester Ascorbate. I. Chemotherapeutic Activity against Candida albicans, Cryptococcus neoformans, and Blastomyces dermatitidis in MiceThe Journal of Infectious Diseases, 1976
- Comparative In Vitro Antifungal Activity of Amphotericin B and Amphotericin B Methyl EsterAntimicrobial Agents and Chemotherapy, 1975
- POLYENE MACROLIDE DERIVATIVES. IIIThe Journal of Antibiotics, 1972
- POLYENE MACROLIDE DERIVATIVES. IThe Journal of Antibiotics, 1972
- Structure and absolute configuration of the polyene macrolide antibiotic amphotericin BTetrahedron Letters, 1970
- The Discovery and Development of Amphotericin BDiseases of the Chest, 1968