Early adversity alters attention and locomotion in adult Sprague-Dawley rats.
- 1 June 2006
- journal article
- Published by American Psychological Association (APA) in Behavioral Neuroscience
- Vol. 120 (3) , 665-675
- https://doi.org/10.1037/0735-7044.120.3.665
Abstract
This study investigated the effects of prenatal stress and its interaction with artificial rearing (AR) on adult rat behavior. Pregnant dams underwent restraint stress from Gestational Day 10 to 21. After parturition, pups were raised by their mothers or in the AR paradigm, with or without stroking stimulation. In adulthood, rats were tested on prepulse inhibition (PPI), locomotor activity, elevated plus-maze, and spatial working memory. There were main effects and interactions of both prenatal stress and AR on activity. Additional stimulation reduced activity in nonstressed AR rats but increased activity in prenatally stressed AR rats. AR altered PPI and plus-maze behavior whereas additional stimulation partially reversed these effects. This study demonstrates that prenatal experiences can modulate the effects of postnatal treatments.Keywords
This publication has 76 references indexed in Scilit:
- Maternal and littermate deprivation disrupts maternal behavior and social‐learning of food preference in adulthood: Tactile stimulation, nest odor, and social rearing prevent these effectsDevelopmental Psychobiology, 2006
- The effects of early rearing environment on the hormonal induction of maternal behavior in virgin ratsHormones and Behavior, 2005
- Mothers in Stress: Consequences for the OffspringAmerican Journal of Reproductive Immunology, 2005
- Maternal Programming of Individual Differences in Defensive Responses in the RatAnnals of the New York Academy of Sciences, 2004
- Beneficial effects of enriched environment on adolescent rats from stressed pregnanciesEuropean Journal of Neuroscience, 2004
- Early adoption modifies the effects of prenatal stress on dopamine and glutamate receptors in adult rat brainJournal of Neuroscience Research, 2004
- Sex differences in learning deficits induced by prenatal stress in juvenile ratsBehavioural Brain Research, 2004
- Influence of Neonatal Rearing Conditions on Stress‐Induced Adrenocorticotropin Responses and Norepinepherine Release in the Hypothalamic Paraventricular NucleusJournal of Neuroendocrinology, 2000
- A Three Year Follow-Up of Attachment and Indiscriminate Friendliness in Children Adopted from Romanian OrphanagesChild Development, 1998
- The Development of Visual Perception in Man and ChimpanzeeScience, 1947