The Immunological Synapse--a Multitasking System
- 22 February 2002
- journal article
- perspective
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 295 (5559) , 1479-1480
- https://doi.org/10.1126/science.1069896
Abstract
The immunological synapse, the interface between the T cell and antigen-presenting cell (APC), is thought to be important for enhancing and sustaining signaling by the T cell receptor after it has engaged antigenic peptide on the APC surface. In a Perspective, van der Merwe and Davis discuss new findings ( Lee et al.) demonstrating that T cell receptor signaling takes place well before formation of the immunological synapse, suggesting that this dynamic structure may have other functions.Keywords
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