In vitro Effect of Ethanol on Subpopulations of Human Blood Mononuclear Cells

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Abstract
Mononuclear cells from 10 healthy blood donors were incubated with ethanol at 37°C for 30 min. An ethanol concentration of 10.0 g/l reduced the percentage of active E rosette-forming cells (E RFC) from 25.0 ± 12.1 to 16.218.7, and the percentage of total E RFC from 70.3 ± 8.5 to 59.7 ± 13.5 (p <0.01 for both). The percentage of cells with phagocytizing capacity was reduced from 11.7 ± 5.4 to 7.0 ± 5.0 by the ethanol treatment (p <0.01). Incubation with ethanol at a concentration of 1.0 g/l also significantly reduced the number of active and total E RFC and of phagocytizing cells. Ethanol at a concentration of 0.1 g/l did not influence these cell subpopulations. The number of EA RFC and EAC RFC were not influenced by ethanol.

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