Peptide synthesis. Part 2. Procedures for solid-phase synthesis using Nα-fluorenylmethoxycarbonylamino-acids on polyamide supports. Synthesis of substance P and of acyl carrier protein 65–74 decapeptide
- 1 January 1981
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 2,p. 538-546
- https://doi.org/10.1039/p19810000538
Abstract
Use of base-labile Nα-9-fluorenylmethoxycarbonylamino-acids in combination with acid-labile t-butyl or p-alkoxybenzyl side-chain or carboxy-terminal (resin-linkage) protecting groups enables solid-phase peptide synthesis to be carried out under exceptionally mild reaction conditions. The repetitive and vigorous acidic treatments required in conventional synthesis are avoided. High-yield syntheses of a decapeptide and of an undecapeptide amide (Substance P) are described using this new combination of protecting groups on polyamide supports.This publication has 2 references indexed in Scilit:
- Peptide synthesis. Part 1. Preparation and use of polar supports based on poly(dimethylacrylamide)Journal of the Chemical Society, Perkin Transactions 1, 1981
- SIDE REACTIONS IN PEPTIDE-SYNTHESIS .7. SEQUENCE DEPENDENCE IN FORMATION OF AMINOSUCCINYL DERIVATIVES FROM BETA-BENZYL-ASPARTYL PEPTIDES1978