Expanding the Scope of C−H Amination through Catalyst Design
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- 9 November 2004
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 126 (47) , 15378-15379
- https://doi.org/10.1021/ja0446294
Abstract
Analysis of the mechanism for Rh-mediated C−H amination has led to the development of a remarkably effective dinuclear Rh catalyst derived from 1,3-benzenedipropionic acid. This unique complex, Rh2(esp)2, is capable of promoting both intra- and intermolecular C−H oxidation reactions, and in all cases is superior to Rh2(O2CtBu)4. For the first time, C−H insertion is described with urea and sulfamide substrates to give 1,2- and 1,3-diamine derivatives, respectively. In addition, intermolecular amination of benzylic and secondary C−H bonds is shown to proceed efficiently even under conditions in which the starting alkane is employed as the limiting reagent.Keywords
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