Mouse Blood Leukocytes: in Vitro Primary and Secondary Responses to Two Synthetic Polypeptides

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Abstract
The antibody responses of various strains of inbred mice to a series of multichain synthetic polypeptide antigens are quantitative traits under a dominant-determinant-specific type of genetic control (1). That is, a given strain of mouse may respond poorly, if at all, to one of the antigens while a second strain will respond quite well. These antigens are composed of a polylysine backbone with side chains of poly-dl-alanine and, in the case of the two antigens used in these experiments, terminating in short random sequences of either tyrosine and glutamic acid [(T,G)-A--L], or histidine and glutamic acid [(H,G)-A--L]. It has been shown that the genetic mechanism controlling these antibody responses is closely linked to the major histocompatibility locus (H-2) of the mouse (2). All strains of the same H-2 type (except H-2d) exhibit a similar pattern of immune response to these antigens regardless of the remainder of the strain's genetic background.

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