Food-induced increase in propranolol bioavailability—Relationship to protein and effects on metabolites

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Abstract
The influence of a meal on the deposition and metabolism of oral propranolol was examined in 6 normal subjects. The meal induced a mean 53% increase in propranolol bioavailability (range, 2%-92%; P < 0.01) without affecting time to maximum concentration, half-life or the amount of unchanged drug in urine. There was no effect on the plasma concentrations of 4-hydroxypropranolol or 4 other metabolites. The increased bioavailability was linearly related to the protein content of the meal (r = 0.884, P < 0.02) above a threshold content of about 7 g.