Metergoline as a selective 5-hydroxytryptamine antagonist in the cerebral cortex
- 1 February 1977
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Physiology and Pharmacology
- Vol. 55 (1) , 130-133
- https://doi.org/10.1139/y77-020
Abstract
In rats anaesthetized with a mixture of methoxyflurane, nitrous oxide, and oxygen, the depressant actions on the cerebral cortical neurones of iontophoretically applied 5-hydroxytryptamine (5-HT) but not of noradrenaline, histamine, AMP, Ca2+, and γ-aminobutyric acid were antagonized by metergoline. These observations indicate that metergoline may be a selective 5-HT antagonist in the cerebral cortex.This publication has 1 reference indexed in Scilit:
- Antagonism of 5-hydroxytryptamine-induced bronchospasm in guinea-pigs by 8β-carbobenzyloxy-aminomethyl-1-methyl-10α-ergolineJournal of Pharmacy and Pharmacology, 1965