Competition of Normal γ-Globulins with Cytophilic Antibody for Corneal Cells

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Abstract
Sections of cornea from normal rabbits when incubated with rabbit antiserum to β-galactosidase (BGZ) and washed were shown to bind BGZ. This passive sensitization is presumably mediated by a ‘cytophilic’ antibody present in the hyperimmune serum. Incubation of the corneal discs with unfractionated normal rabbit serum or its γ2-IgG fractions, significantly reduced the ability of the discs to bind cytophilic antibody. This inhibition was produced only by normal γ2-IgG and not by γ1-IgG which indicates the presence of specific receptors on cell surfaces for binding cytophilic antibody. Preemption of these receptors and thereby inhibition of passive sensitization of cornea by normal γ2-globulin is presented as a possible means to reduce the manifestations of allergic responses in the eye.

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