The persistence of benzo[a]pyrene diol-expoxide deoxyguanosine adduct in mouse skin and its disappearance in rat skin
- 1 December 1983
- journal article
- research article
- Published by Oxford University Press (OUP) in Carcinogenesis: Integrative Cancer Research
- Vol. 4 (12) , 1655-1657
- https://doi.org/10.1093/carcin/4.12.1655
Abstract
Male Swiss mice and Wistar rats, susceptible and resistant, respectively, to the carcinogenic effects of benzo[a]pyrene, were treated topically with 250 nmol/mouse and 1000 nmol/rat of tritium labelled benzo[a]pyrene (BaP). The initial formation of BaP diol-epoxide deoxyguanosine adduct was approximately similar in the skin epidermis of the two species. After 3 weeks, the persistence of some 6.5% of initial BaP diol-epoxide deoxyguanosine was observed in mouse skin DNA, while this adduct was completely removed from DNA of rat skin. The total excision of BaP diol-epoxide deoxyguanosine adduct in rat epidermis may contribute in part for the relative resistence of rat skin to the carcinogenic actions of BaP.Keywords
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