Dynamic Disturbances of Intrathyroid Iodine Metabolism in Sporadic Nontoxic Goiter

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Abstract
A quantitative study of the dynamic aspects of thyroid secretion has been carried out in patients with sporadic nontoxic goiter living in Belgium. There is a functional heterogeneity of thyroid tissue, that is, the existence of a rapidly utilizable and renewable iodine pool alongside one or more glandular pools with a slow turnover. Only part of the iodine stored in the thyroid is effectively utilized. In the patients studied here, the true secretory activity falls within normal limits.

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