Determination of medetomidine, atipamezole and midazolam in pig plasma by liquid chromatography‐mass spectrometry

1 July 1995

journal article
research article
Published by Wiley in Biomedical Chromatography

Vol. 9 (4) , 188-191
https://doi.org/10.1002/bmc.1130090408

Abstract

Medetomidine, atipamezole and midazolam in pig plasma were determined by liquid chromatography‐mass spectrometry (LCMS) with an atmospheric pressure chemical ionization interface system by the use of detomidine as an internal standard. The method was applied to studies of pharmacokinetic behaviour of these drugs.

Keywords

This publication has 6 references indexed in Scilit:

Liquid chromatography-mass spectrometry for the determination of medetomidine and other anaesthetics in plasma
Journal of Chromatography A, 1993
Sedative Effects of Medetomidine in Pigs.
The Journal of Veterinary Medical Science, 1992
Pharmacological effects and pharmacokinetics of atipamezole, a novel alpha 2‐adrenoceptor antagonist‐a randomized, double‐blind cross‐over study in healthy male volunteers.
British Journal of Clinical Pharmacology, 1990
The determination of total and unbound midazolam in human plasma. A comparison of high performance liquid chromatography, gas chromatography and gas chromatography/mass spectrometry
Biomedical Chromatography, 1990
Biotransformation of medetomidine in the rat
Xenobiotica, 1990
A pharmacokinetic analysis program (multi) for microcomputer.
Journal of Pharmacobio-Dynamics, 1981