THE INHIBITION OF HYPOPHYSECTOMY-INDUCED CHANGES IN THE RAT SUBMAXILLARY GLANDS1

Abstract
Thyroxine in combina-tion with testosterone was effective in preventing both tubular atrophy and reduced protease activity in submaxillary glands. Either substance alone only partially prevented these changes. Of the other hormones which were evaluated, only cortisone and pituitary growth hormone exhibited any effect on the submaxillary glands. Insulin, estradiol and progesterone were ineffective. A correlation was noted between the size of the submaxillary granular tubules and the degree of protease activity.