The Effect of Calcium Infusion and Calcitonin on PlasmaPhosphate in Sham-Operated and Thyroparathyroidectomized Dogs1

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Abstract
The effect of iv calcium infusion (1.6 mg Ca/min as acetate or chloride) on plasma phosphate concentration was studied in dogs. Comparisons were made between sham-operated (TI), thyroparathyroidectomized (TPTX), and TPTX dogs administered calcitonin (50 MRC U × 2) during the calcium infusion. In anesthetized animals infused with calcium, a rise in plasma phosphate values was seen only in TPTX dogs. Subcutaneous calcitonin administration prevented this rise in TPTX dogs. Saline-infused controls, and urinary excretion measurements support the conclusion that the effects observed did not result from the presence or absence of parathyroid hormone. The results of these experiments demonstrate that calcitonin, from either endogenous or exogenous sources, prevents or reduces the rise in plasma phosphate concentration which would otherwise occur following calcium infusion in this species. This study supports the recent finding in rats that an important previously unrecognized role of calcitonin may be to moderate the hyperphosphatemia resulting from calcium administration. (Endocrinology93: 1222, 1973)

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