Sequences Present in Both Human Leukemic Cell Nuclear DNA and Rauscher Leukemia Virus
- 1 July 1974
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 71 (7) , 2853-2857
- https://doi.org/10.1073/pnas.71.7.2853
Abstract
DNA synthesized by particulate fractions from human leukemic white blood cells has been subfractionated by hybridization to Rauscher leukemia virus 70S RNA followed by hydroxylapatite chromatography. The Rauscher-leukemia-virus-specific DNA fraction is shown to be complementary only to sequences present in the nuclear DNA of Balb/c mouse spleens infected by this virus and the nuclear DNA from human leukemic white blood cells, and not to sequences present in the nuclear DNA of normal Balb/c mouse spleens or the nuclear DNA of normal human white blood cells.Keywords
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