The role of p53 in the immunobiology of cutaneous squamous cell carcinoma
- 29 May 2003
- journal article
- review article
- Published by Oxford University Press (OUP) in Clinical and Experimental Immunology
- Vol. 132 (3) , 379-384
- https://doi.org/10.1046/j.1365-2249.2003.02159.x
Abstract
Cutaneous squamous cell carcinoma is typically characterized by the over-expression of the tumour suppressor protein p53. Considerable evidence suggests that immune competence is important in the control of cutaneous SCC. We discuss the immunobiology of p53 and its relevance to cutaneous SCC, including the potential interaction with human papillomavirus.Keywords
This publication has 92 references indexed in Scilit:
- Epidermodysplasia Verruciformis Defines a Subset of Cutaneous Human PapillomavirusesJournal of Virology, 2001
- Cutaneous Squamous-Cell CarcinomaNew England Journal of Medicine, 2001
- Histopathology of incipient intraepidermal squamous cell carcinoma (?actinic keratosis?)Journal of the American Academy of Dermatology, 2000
- Human p53264–272 HLA-A2 binding peptide is an immunodominant epitope in DNA-immunized HLA-A2 transgenic miceCancer Letters, 1999
- Tumor Eradication by Wild-type p53-specific Cytotoxic T LymphocytesThe Journal of Experimental Medicine, 1997
- Primary proliferative T cell response to wild‐type p53 protein in patients with breast cancerEuropean Journal of Immunology, 1995
- Mapping and ranking of potential cytotoxic T epitopes in the p53 protein: effect of mutations and polymorphism on peptide binding to purified and refolded HLA moleculesEuropean Journal of Immunology, 1995
- CD4+ T lymphocyte infiltration correlates with regression of a UV-induced squamous cell carcinomaJournal of Dermatological Science, 1995
- Flow-cytometric determination of peptide-class I complex formation identification of p53 peptides that bind to HLA-A2Human Immunology, 1994
- In vitro induction of human cytotoxic T lymphocyte responses against peptides of mutant and wild‐type p53European Journal of Immunology, 1993