Palladium-Catalyzed Amination of Aryl Halides on Solid Support
- 27 November 2002
- journal article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 4 (26) , 4689-4692
- https://doi.org/10.1021/ol027119s
Abstract
The first examples of the Pd(0)-catalyzed amination of aryl halides using Rink-resins as nitrogen source are described. Pd2dba3/BINAP/NaO-t-Bu was found to be the most efficient catalyst/base system, while a solvent mixture of dioxane and tert-butyl alcohol was shown to enhance the selectivity toward the desired monoarylation. Moderate to good yields and excellent purities of the amination products were found with electron-poor aryl halides, while electon-rich aryl halides failed to react under these conditions.Keywords
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