In-situ-Isolated Perfused Rat Pancreas: a New Method for Pharmacological Studies of the Exocrine Pancreas

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Abstract
A method of in-situ-isolated perfused rat pancreas is described. In situ perfusion of the isolated rat pancreas allows a faster set-up due to a simpler operating procedure. The sensitivity of the isolated rat pancreas was tested with secretin and cholecystokinin. The pancreas responds to doses of secretin as low as 0.005 CU[clinical units]/kg.cntdot.h. Such a highly sensitive model might prove to be useful for the bioassay of secretin and the study of the effects of pancreatic secretagogues.

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