ON THE MODE OF ACTION OF CALCIFEROL IN THE NEPHRECTOMIZED RAT

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Abstract
The subcut. adm. of massive doses of calciferol prevented the fall in serum Ca which usually occurs after thyroparathyroidectomy in the nephrectomized rat. Calciferol produced no observable effect on the serum Ca of the nephrectomized rat that was thyroparathyroidec-tomized 1 wk. prior to nephrectomy. The action of calciferol is apparently in the bowel, where it decreases the fecal excretion of Ca.

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