Genetic effects in Brazilian populations due to consanguineous marriages

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Abstract
Estimates of “relative risks” and “attributable risks” are presented for two Brazilian regions with the lowest (F=0.00030) and the highest (F=0.00395) inbreeding levels of the country, and for the whole country (F=0.00088). The abolition of all consanguineous marriages (from second cousins up to and including uncle‐niece/aunt‐nephew marriages) in Brazil would eliminate only about 0.22, 3.05, and 0.65% of the “total damage,” respectively. “Total damage” is defined as including abortions, miscarriages, stillbirths, infant‐Juvenile mortality (up to the age of 20 years), and anomalies in the survivors. The reduction of prenatal damage would be 0.11, 1.46, and 0.31%, and that of postnatal damage would be 0.49, 6.65, and 1.36%, respectively.